Regulation of Phospholipase D2 Activity by Protein Kinase Cα
نویسندگان
چکیده
منابع مشابه
Regulation of Phospholipase D2 Activity by Protein Kinase C *
It has been well documented that protein kinase C (PKC) plays an important role in regulation of phospholipase D (PLD) activity. Although PKC regulation of PLD1 activity has been studied extensively, the role of PKC in PLD2 regulation remains to be established. In the present study it was demonstrated that phorbol 12myristate 13-acetate (PMA) induced PLD2 activation in COS-7 cells. PLD2 was als...
متن کاملRegulation of phospholipase D2 activity by protein kinase C alpha.
It has been well documented that protein kinase C (PKC) plays an important role in regulation of phospholipase D (PLD) activity. Although PKC regulation of PLD1 activity has been studied extensively, the role of PKC in PLD2 regulation remains to be established. In the present study it was demonstrated that phorbol 12-myristate 13-acetate (PMA) induced PLD2 activation in COS-7 cells. PLD2 was al...
متن کاملRegulation of Phospholipase D2 Activity by Protein Kinase
It has been well documented that protein kinase C (PKC) plays an important role in regulation of phospholipase D (PLD) activity. Although PKC regulation of PLD1 activity has been studied extensively, the role of PKC in PLD2 regulation remains to be established. In the present study it was demonstrated that phorbol 12myristate 13-acetate (PMA) induced PLD2 activation in COS-7 cells. PLD2 was als...
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Bones' strength is achieved and maintained through adaptation to load bearing. The role of the protein kinase PKCα in this process has not been previously reported. However, we observed a phenotype in the long bones of Prkca(-/-) female but not male mice, in which bone tissue progressively invades the medullary cavity in the mid-diaphysis. This bone deposition progresses with age and is prevent...
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James P. MADIGAN*†, Brian O. BODEMANN†, Donita C. BRADY†‡, Brian J. DEWAR‡, Patricia J. KELLER†‡, Michael LEITGES§, Mark R. PHILIPS‖, Anne J. RIDLEY¶, Channing J. DER*‡** and Adrienne D. COX*†‡**1 *Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, U.S.A., †Department of Radiation Oncology, University of North Carolina at Chapel Hil...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2004
ISSN: 0021-9258
DOI: 10.1074/jbc.m311033200